New Study: Bone Marrow Concentrate (BMC) Shown Superior to Platelet Rich Plasma (PRP) for Ischemic Limb Healing

May 9

New Study: Bone Marrow Concentrate (BMC) Shown Superior to Platelet Rich Plasma (PRP) for Ischemic Limb Healing

New study shows when Bone Marrow Concentrate (BMC)
is combined with Platelet Rich Plasma (PRP), it has more powerful effects than PRP alone to heal ischemic limbs.

Platelet-rich plasma (PRP) is a safe and cost-effective source of growth factors that stimulate cells to repair tissue. Bone marrow cells may be effective in management of chronic skin ulcers. Combining these two properties, a research group set out to determine the impact of PRP derived from two sources in the body, peripheral blood (pb-PRP) versus bone marrow (bm-PRP), in treating wounds on ischemic limbs.

Wounds on ischemic limbs are notorious for healing poorly because they lack adequate blood flow. In addition, it is estimated that the number of chronic wounds on ischemic limbs will multiply due to increased amounts of peripheral arterial diseases worldwide.

The study showed that bm-PRP cells injected into wounds remained at the injury site 4 weeks compared to just 2 weeks for pb-PRP, and that wounds injected with bm-PRP showed a significantly smaller skin defect area compared to pb-PRP at all time periods measured during healing.

In conclusion, wound healing on ischemic limbs was accelerated with bm-PRP, but pb-PRP was no better than placebo saline.


This study may have implications for orthopaedic injuries and will be discussed at the upcoming TOBI 4th Annual PRP & Regenerative Medicine Symposium, June 7-8 (, along with the recent study by Mitchell B. Sheinkop, MD: Functional Outcomes after Bone Marrow Stem Cell Interventions in the Osteoarthritic Hip and Knee; Results at One Year

More research is needed in orthopedics to understand how bone marrow with PRP may benefit bone disease and serve as an effective non-surgical treatment option for orthopedic injuries throughout the body including tendon and joint pain.

Join field leaders advancing biologics to discuss the latest research, clinical experiences and best-practices. Now more than ever is the time to work together and create protocols and standardization of our exploding field. Attend TOBI live or online, details at

CME Cadaver Lab: Hands-on Ultrasound-guided Injections & Bone Marrow Aspirate will sell out – Secure your spot at

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