The Anti-inflammatory and Matrix Restorative Mechanisms of Platelet Rich Plasma in Osteoarthritis recently published by Dr. Brian Cole, MD, The Orthobiologic Institute TOBI Faculty Speaker at the upcoming PRP & Regenerative Medicine Symposium with Cadaver Lab, June 6-7, 2014 in Las Vegas, www.prpseminar.com
Emerging research continues to advocate the use of Platelet Rich Plasma (PRP) in the treatment of osteoarthritis. In a controlled laboratory study out of Cornell University, PRP and high molecular weight hyaluronic acid (HA) were used to treat Osteoarthritis cartilage and synoviocytes, and the specific gene expression and inflammatory mediators were assessed. The study was performed by co-harvesting synovium and cartilage cells with PRP and hyaluronic acid in patients undergoing total knee arthroplasty.
The study revealed that the TNF-Alpha concentration was decreased in the presence of PRP and HA versus the control, while Il-6 concentration was decreased more in the HA group in comparison to the PRP and control groups. In addition, synoviocyte MMP-13 expression was decreased more in the PRP group than with the HA group, while synoviocyte expression of HAS-2 was increased in the PRP group.
Furthermore, the expression of ACAN and COL1A1 in cartilage cells showed discrepancies between HA and PRP, but neither was different from the control group.
Although both HA and PRP treatments revealed decreased catabolic effects on synovial and cartilaginous cells, only the PRP group revealed decreased MMP-13 expression, increased HAS-2 expression, and increased anabolic effects on cartilage.
The results contribute more evidence to the growing theory that PRP not only decreases cartilage catabolism in osteoarthritis, but also increases the endogenous production of HA. The anti-inflammatory and pain reducing qualities of PRP exhibited in this study support its use in the treatment of osteoarthritis. More research and clinical trials are needed to investigate the efficacy and mechanism of PRP in osteoarthritis application.
Abstract: The Anti-inflammatory and Matrix Restorative Mechanisms of Platelet-Rich Plasma in Osteoarthritis
Emily A. Sundman, DVM, Brian J. Cole, MD, MBA, Vasili Karas, MD, Craig Della Valle, MD, Mathew W. Tetreault, MD, Hussni O. Mohammed, DVM, PhD and Lisa A. Fortier, DVM, PhD
The American Journal of Sports Medicine, 2013 Nov 5 [epub ahead of print]
Join Dr. Brain Cole and field leaders at The Orthobiologic Institute TOBI 5th Annual PRP & Regenerative Medicine Symposium with Cadaver Lab, June 6-7, 2014 in Las Vegas, or stream online. Register online at www.prpseminar.com
Don’t miss this important opportunity to work together and create protocols and standardization of our growing field. We look forward to having you with us in June.