End of the Year Wrap-Up: Studies in Regenerative Medicine by TOBI Faculty, October – December 2016

Jan 19

End of the Year Wrap-Up: Studies in Regenerative Medicine by TOBI Faculty, October – December 2016

TOBI Faculty & Alumni Fall Publications: October – December 2016

OCTOBER

October 2016, Orthopedic Journal of Sports Medicine
Mechanoreceptor Reinnervation of Autografts Versus Allografts After Anterior Cruciate Ligament Reconstruction.
This study, published in the Orthopedic Journal of Sports Medicine, focused onthe presence or absence of mechanoreceptors between allograft versus autograft after ACL reconstruction in humans. Longtime TOBI Faculty Jason Dragoo, MD of Stanford published in October 2016.
See the full study here.

October 2016, Knee Surgery Sports Traumatology Arthroscopy.
The efficacy of post-operative devices following knee arthroscopic surgery: a systematic review
TOBI Speaker & Faculty Jason Dragoo, MD continues his ACL research with this study, published in Knee Surgery Sports Traumatology Arthroscopy. There is a wide array of device modalities available for post-operative treatment following arthroscopic knee surgery; however, it remains unclear which types and duration of modality are the most effective. This systematic review aimed to investigate the efficacy of device modalities used following arthroscopic knee surgery.
See the full study here.

October 2016, Journal of Ultrasound in Medicine
Ultrasound Findings of Delayed-Onset Muscle Soreness
Longtime TOBI Faculty members Jon A. Jacobson and Kenneth Mautner published this study together, the purpose of which was to retrospectively characterize the ultrasound findings of delayed-onset muscle soreness (DOMS).
See the full study here.

October 2016, American Journal of Sports Medicine
Biomechanical Effects of an Injury Prevention Program in Preadolescent Female Soccer Athletes.
Furthering even more his cutting-edge ACL research, Jason Dragoo, MD led a study on the effects of an injury-prevention warm-up program on changes to biomechanical risk factors for an ACL injury in preadolescent female soccer players. This study provides motivation for enhancing injury prevention programs to produce improvement in other ACL risk factors.
See the full study here.

October 2016, Osteoarthritis and Cartilage
Macroscopic cartilage repair scoring of defect fill, integration and total points correlate with corresponding items in histological scoring systems – a study in adult sheep.
TOBI 2016 Speaker Henning Madry, MD, of Saarland University Medical Center in Germany conducted a study to correlate osteochondral repair assessed by validated macroscopic scoring systems with established semiquantitative histological analyses in an ovine model, and to test the hypothesis that important macroscopic individual categories correlate with their corresponding histological counterparts. They concluded that macroscopy allows to precisely predict key histological aspects of articular cartilage repair, underlining the specific value of macroscopic scoring for examining cartilage repair.
See the full study here.

October 2016, Stem Cells International
Modulation of Synovial Fluid-Derived Mesenchymal Stem Cells by Intra-Articular and Intraosseous Platelet Rich Plasma Administration.
The aim of this study, by TOBI faculty alumni Mikel Sanchez, Nicolas Fiz, and Sabino Padilla, was to evaluate the effect of intra-articular (IA) or a combination of intra-articular and intraosseous (IO) infiltration of Platelet Rich Plasma (PRP) on the cellular content of synovial fluid (SF) of osteoarthritic patients.
See the full study here.

 

NOVEMBER

November 2016, Physical Medicine and Rehabilitation Clinics of North America
Platelet Rich Plasma
New TOBI 2017 Speaker and MSK Ultrasound Lab Director Joanne Borg-Stein, MD contributed to this article, which reviews the latest basic science on PRP, clinical evidence for its use in musculoskeletal medicine, limitations in current knowledge, and critical areas for future research.
See the full study here.

November 2016, Journal of Ultrasound in Medicine
Greater Trochanteric Pain Syndrome: Percutaneous Tendon Fenestration Versus Platelet-Rich Plasma Injection for Treatment of Gluteal Tendinosis.
This fascinating study by longtime TOBI faculty Jon A. Jacobson, MD compares ultrasound-guided percutaneous tendon fenestration to platelet-rich plasma (PRP) injection for treatment of greater trochanteric pain syndrome. Results showed that both ultrasound-guided tendon fenestration and PRP injection are effective for treatment of gluteal tendinosis.
See the full study here.

 November 2016, International Orthopedics
Local transplantation of bone marrow concentrated granulocytes precursors can cure without antibiotics infected nonunion of polytraumatic patients in absence of bone defect.
International TOBI Speaker Dr. Philippe Hernigou explore new and alternative therapies to address infected, long bone non-unions in this study in International Orthopedics.
See the full study here.

November 2016, Expert Opinion on Biological Therapies
Platelet-rich plasma, a source of autologous growth factors and biomimetic scaffold for peripheral nerve regeneration.
This review addresses current molecular and cellular data in intrinsic nerve repair processes and describes different strategies to harness and enhance processes by using biochemical and biomechanical cues. It focuses on autologous fibrin, plasma and platelet-derived growth factors as filler or scaffolds that can synergize with the gold standard therapy and other nerve guidance conduits. Expert opinion: PRP is applied as a filler of nerve conduits or vein-muscle grafts across nerve gaps post trauma by infiltrating the nerve stumps perineurally and intraneurally in neuropathies, or as scaffolds to bridge or wrap nerve stumps, with significant neurological recovery and pain reduction.
See the full study here.

November 2016, Cells, Tissues, Organs
Muscle Injuries and Repair: What’s New on the Horizon
TOBI Faculty and alumni Johnny Huard, MD, of University of Texas Health Science Center at Houston, published a comprehensive overview to to highlight current knowledge, outline recent advances, and to discuss the evolving paradigms in skeletal muscle injury and repair.
See the full study here.

November 2016, The Journal of Bone & Joint Surgery
What’s New in Orthopaedic Rehabilitation
TOBI Faculty William Murrell, MD, along with his co-authors, compiled an update of evidence of the research in Orthopaedic Rehabilitation from 2015 -2016. They screened evidence from studies published in American Journal of Physical Medicine & Rehabilitation, The American Journal of Sports Medicine, Archives of Physical Medicine and Rehabilitation, The Clinical Journal of Pain, JAMA, The Journal of Bone & Joint Surgery, The Journal of Pain, Journal of Shoulder and Elbow Surgery, The New England Journal of Medicine, Physical Therapy, and PM&R.
See the full compilation here.

November 2016, Physical Medicine and Rehabilitation Clinics of North America
Orthobiologics and Knee Osteoarthritis: A Recent Literature Review, Treatment Algorithm, and Pathophysiology Discussion.
TOBI Faculty Kristin Oliver, MD, contributed to this article, which reviews the current options in orthobiologics for the clinical treatment of knee osteoarthritis (OA), including discussions of graft choice and patient selection in the current state of understanding of the treatment of knee OA in a tissue engineering model with orthobiologics.
Access the full study here.

November 2016, Physical Medicine and Rehabilitation Clinics of North America
Regenerative Approaches to Tendon and Ligament Conditions.
TOBI Faculty Brian J. Shiple reviews biocellular and orthobiologic approaches including PRP and stem cell therapies, as well as some of the regenerative medicine science and difficulties facing physicians exploring these methods.
See the full study here.

November 2016, American Journal of Sports Medicine
Anterior Cruciate Ligament-Derived Stem Cells Transduced With BMP2 Accelerate Graft-Bone Integration After ACL Reconstruction.
The purpose of this study, by TOBI Faculty Johnny Huard, MD, at the University of Pittsburgh, was to identify strategies that accelerate graft-bone integration. Huard studied whether the application of ACL-derived stem cells with enhanced expression of bone morphogenetic protein 2 (BMP2) onto soft tissue grafts in the form of cell sheets will both accelerate and improve the quality of graft-bone integration after ACL reconstruction in a rat model.
See the full study here. 

DECEMBER

December 2016, Journal of Experimental Orthopedics
The effect of foot landing position on biomechanical risk factors associated with anterior cruciate ligament injury.
Stanford-based TOBI Speaker and Faculty Jason L. Dragoo published this study, which examines the effect of foot landing postion on risk factors associated with anterior cruciate ligament injury. They concluded that toe-in landing position exacerbates biomechanical risk factors associated with ACL injury, while toe-out landing position decreases these factors.
See the full study here.

December 2016, American Journal of Sports Medicine
The Use of Platelet-Rich and Platelet-Poor Plasma to Enhance Differentiation of Skeletal Myoblasts.
Dr. Jason Dragoo, long-time TOBI Faculty, continues his PRP research with this study, of which the purpose was to compare the effects of the following non-neutrophil-containing (leukocyte-poor) plasma fractions on human skeletal muscle myoblast (HSMM) differentiation: (1) PRP, (2) modified PRP (Mod-PRP), in which transforming growth factor β1 (TGF-β1) and myostatin (MSTN) were depleted, and (3) platelet-poor plasma (PPP). The hypothesis was that leukocyte-poor PRP would lead to myoblast proliferation (not differentiation), whereas certain modifications of PRP preparations would increase myoblast differentiation, which is necessary for skeletal muscle regeneration.
See the full study here.

December 2016, Foot and Ankle Clinics
Orthobiologics in the Foot and Ankle.
From our TOBI 2016 Speaker H. Thomas Temple: Many allogeneic biologic materials, by themselves or in combination with cells or cell products, may be transformative in healing or regeneration of musculoskeletal bone and soft tissues. By reconfiguring the size, shape, and methods of tissue preparation to improve deliverability and storage, unique iterations of traditional tissue scaffolds have emerged. These new iterations, combined with new cell technologies, have shaped an exciting platform of regenerative products that are effective and provide a bridge to newer and better methods of providing care for orthopedic foot and ankle patients.
See the full study here.

December 2016, American Journal of Sports Medicine
Anterior Cruciate Ligament-Derived Stem Cells Transduced With BMP2 Accelerate Graft-Bone Integration After ACL Reconstruction.
TOBI Faculty Johnny Huard, MD, published this study in the American Journal of Sports Medicine to identify strategies that accelerate graft-bone integration, which would reduce the time to biologic fixation, improve the reliability of biologic fixation, allow for accelerated rehabilitation, and potentially reduce the incidence of early graft pullout and late midsubstance failure after ACL reconstruction.
See the full study here.

December 2016, Journal of Experimental Orthopedics
Bone marrow aspirate concentrate for the treatment of osteochondral lesions of the talus: a systematic review of outcomes.
The goal of this study, done by TOBI faculty Thomas O’Clanton, MD and published in the Journal of Experimental Orthopedics, was perform a systematic review on the outcomes of bone marrow aspirate concentrate (BMAC) for the treatment of chondral defects and osteoarthritis (OA) of the talus.
See the full study here.

December 2016, Musculoskeletal Surgery
Hip arthroscopy complications regarding surgery and early postoperative care: retrospective study and review of literature.
Internationally-known TOBI Speaker and Faculty Ramon Cugat published this study in Musculoskeletal Surgery, which describes the rate of complications in a series of hip arthroscopies performed at his center, as well as performing a systematic review of the current literature in order to compare outcomes.
See the full study here.

 

For the latest orthobiologics research and best practices from global field leaders, join us at TOBI 2017:

The Orthobiologic Institute (TOBI)
7th Annual PRP & Regenerative Medicine Symposium with Workshops & Cadaver Labs (TOBI 2017)
June 8-10, 2017
Wynn, Las Vegas, NV

www.prpseminar.com

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