The Orthobiologic Institute (TOBI) alumni and faculty member Dr. Adam Anz from The Andrews Research and Education Institute publishes review article on application of biologics in orthopaedics:
Dr. Adam Anz, previous TOBI Faculty from The Andrews Research and Education Institute, recently published a review article in the Journal of the American Academy of Orthopaedic Surgeons titled Application of Biologics in the Treatment of the Rotator Cuff, Meniscus, Cartilage, and Osteoarthritis.
The article discusses many aspects of available biologic treatments used in orthopaedics, including the basic science behind them and the legality of such treatments. Anz provides substantial overview of the science behind the therapeutic potential of platelet rich plasma (PRP) and other cell based therapies like bone marrow aspirate (BMA) and peripheral blood stem cells. In addition, the FDA classification of these products and the implications of governing regulations is also discussed.
However, much of the article focuses on the specific application of biologics in orthopaedics. The article reviews the preclinical and clinical evidence for use of PRP and/or BMA in rotator cuff repair, meniscus repair, cartilage repair, and osteoarthritis. For each application, the methods and results of clinical and animal studies are reviewed. Topics such as genetic modification of stem cells and the use of scaffolding as a substrate are examined. More specifically, how these cellular manipulations affect FDA classifications and future research efforts. The article concludes with a summary of the authors’ positive experience with the use of PRP and BMA in osteoarthritis.
The review provides a concise summary of current research and clinical applications for biologic therapies in orthopaedics, while discussing the important federal regulations governing the use and classification of these products. Future clinical research in the field, through appropriate regulatory channels, is needed to further substantiate current research results and increase clinical application of biologics.
For more of the latest research on regenerative medicine and hands-on musculoskeletal ultrasound cadaver lab, be sure to attend the 6th Annual TOBI: The Orthobiologic Institute PRP & Regenerative Medicine Symposium with Cadaver Lab June 12-14, 2015 in Las Vegas,www.prpseminar.com Save $300 OFF Registration with Promo Code: TOBIBLOG